dna molecule – Pimac – Biotech Investment Management Center

09 Feb

Encapsulation and Outdoor Testing of Perovskite Solar Cells: Comparing Industrially Relevant Process with a Simplified Lab Procedure

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Perovskite solar cells (PSCs) have shown great potential for next-generation photovoltaics. One of the main barriers to their commercial use is their poor long-term stability under ambient conditions and, in particular, their sensitivity to moisture and oxygen. Therefore, several encapsulation strategies are being developed in an attempt to improve the stability of PSCs in a humid environment. The lack of common testing procedures makes the comparison of encapsulation strategies challenging. In this paper, we optimized and investigated two common encapsulation strategies: lamination-based glass-glass encapsulation for outdoor operation and commercial use (COM) and a simple glue-based encapsulation mostly utilized for laboratory…

Development and Evaluation of Lyophilized Methotrexate Nanosuspension using Quality by Design Approach

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With the application of the quality by design (QbD) approach, a high-pressure homogenizer (HPH) methodology was employed to develop methotrexate nanosuspension (MTX-NS) to boost bioavailability. The Ishikawa diagram was used to analyze potential risk factors in formulation development. To screen and study the impact of various formulation and process factors on the critical quality attributes (CQA), the Placket-Burman design and central composite design were utilized. The number of HPH cycles, poloxamer 188 concentration, and tween 80 concentration were shown to be significant parameters (P<0.05), that were further optimized using Central Composite Design. The zeta potential of optimized lyophilized MTX-NS was determined to…

Implementation of large-scale laboratory-based detection of COVID-19 in the Veterans Health Administration, March 2020 – February 2021

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presented numerous operational challenges to healthcare delivery networks responsible for implementing large scale detection of Coronavirus Disease 2019 (COVID-19), the infection caused by SARS-CoV-2. We describe testing performance, review data quality metrics, and summarize experiences during the scale up of laboratory-based detection of COVID-19 in the Veterans Health Administration, the largest healthcare system in the United States. During March 2020 to February 2021, we observed rapid increase in testing volume, decreases in test turnaround time, improvements in testing of hospitalized persons, changes in test positivity, and varying utilization of different tests. Though performance…