Publications

Applying Computational Fluid Dynamics in the Development of Smart Ripening Rooms for Traditional Cheeses

Traditional ewe's cheese producers face certain challenges caused by fluctuating environmental parameters inside the ripening room, which lead to lack of homogeneity in the final product. The present research discusses the application of computer fluid dynamics for simulating the distribution of environmental parameters, predicting the airflow pattern, and identifying critical areas where such parameters could cause reduced cheese quality. A new monitoring system was developed including presence sensors, temperature and humidity dataloggers, pneumatic actuators, microcontrollers, and microcomputers connected remotely for control, data visualization, and processing. The validation of the computer simulation and monitoring system was made with a batch of 40 ewe's cheeses distributed in…
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A CMOS Integrator-Based Clock-Free Time-to-Digital Converter for Home-Monitoring LiDAR Sensors

This paper presents a nine-bit integrator-based time-to-digital converter (I-TDC) realized in a 180 nm CMOS technology for the applications of indoor home-monitoring light detection and ranging (LiDAR) sensors. The proposed I-TDC exploits a clock-free configuration so as to discard clock-related dynamic power consumption and some notorious issues such as skew, glitch, and synchronization. It consists of a one-dimensional (1D) flash TDC to generate coarse-control codes and an integrator with a peak detection and hold (PDH) circuit to produce fine-control codes. A thermometer-to-binary converter is added to the 1D flash TDC, yielding four-bit coarse codes so that the measured detection range can be…
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Delivery of superoxide dismutase by TAT and Abalone peptides for the protection of skin cells against oxidative stress

Trichoderma reesei superoxide dismutase (TrSOD) is a well characterized enzyme being stable between 30 and 90°C for 1 h with activity at pH between 2.6 and 9.0. This work aimed to clone, express, purify and evaluate the protective effect antioxidant of this enzyme on skin cells when fused to transactivator of transcription (TAT) protein transduction domain of HIV-1 and Abalone (Ab) peptides to allow cell penetration. TrSOD, TAT-TrSOD-Yfp (fused to yellow fluorescent protein) and Ab-TrSOD were expressed in E.coli and purified as soluble proteins. The cytotoxicity of the enzymes, at the concentrations of 1, 3 and 6 μmol/L, was evaluated for a…
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A CRISPR toolbox for generating intersectional genetic mouse models for functional, molecular, and anatomical circuit mapping

Background: The functional understanding of genetic interaction networks and cellular mechanisms governing health and disease requires the dissection, and multifaceted study, of discrete cell subtypes in developing and adult animal models. Recombinase-driven expression of transgenic effector alleles represents a significant and powerful approach to delineate cell populations for functional, molecular, and anatomical studies. In addition to single recombinase systems, the expression of two recombinases in distinct, but partially overlapping, populations allows for more defined target expression. Although the application of this method is becoming increasingly popular, its experimental implementation has been broadly restricted to manipulations of a limited set of common…
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Distinct Developmental Features of Olfactory Bulb Interneurons

Distinct Developmental Features of Olfactory Bulb Interneurons

ABSTRACT The olfactory bulb (OB) has an extremely higher proportion of interneurons innervating excitatory neurons than other brain regions, which is evolutionally conserved across species. Despite the abundance of OB interneurons, little is known about the diversification and physiological functions of OB interneurons compared to cortical interneurons. In this review, an overview of the general developmental process of interneurons from the angles of the spatial and temporal specifications was presented. Then, the distinct features shown exclusively in OB interneurons development and molecular machinery recently identified were discussed. Finally, we proposed an evolutionary meaning for the diversity of OB interneurons. INTRODUCTION…
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Do the Walkability and Urban Leisure Amenities of Neighborhoods Affect the Body Mass Index of Individuals? Based on a Case Study in Seoul, South Korea.

Do the Walkability and Urban Leisure Amenities of Neighborhoods Affect the Body Mass Index of Individuals? Based on a Case Study in Seoul, South Korea.

This study investigates the impact of neighborhood-built environments on obesity in interrelationship with socioeconomic status (SES)-controlling for dietary patterns and physical activities of residents-using structural equation modeling (SEM). A total of 577 samples who are between 19 and 64 years old and reside in Seoul are extracted from Korea National Health and Nutrition Examination Survey (KNHNES), 2015. Neighborhood environments are represented as the two latent constructs-walkability and leisure amenities-composited with indicators such as density of intersections, density of mixed-use area, and the area of open spaces and are aggregated by jurisdictional unit in Seoul. We found that greater walkability in…
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