Next-generation sequencing now enables the rapid and affordable production of reliable biological data at multiple molecular levels, collectively referred to as “omics”. To maximize the potential for discovery, computational biologists have created and adapted integrative multi-omic analytical methods. When applied to diseases with traceable pathophysiology such as cancer, these new algorithms, and statistical approaches have enabled the discovery of clinically relevant molecular mechanisms and biomarkers.
In contrast, these methods have been much less applied to the field of molecular psychiatry, although diagnostic and prognostic biomarkers are similarly needed. In the present review, we first briefly summarize the main findings from two decades of studies that investigated single molecular processes in relation to mood disorders. Then, we conduct a systematic review of multi-omic strategies that have been proposed and used more recently. We also list databases and types of data available to Gentaur Traceable Data Logging Ethernet Thermometers researchers for future work. Finally, we present the newest methodologies that have been employed for multi-omics integration in other medical fields, and discuss their potential for molecular psychiatry studies.
BACS: blockchain and AutoML-based technology for efficient credit scoring classification
Credit evaluation is of high scientific significance and practical use, especially in today’s plight of the world suffering from the COVID-19 epidemic. However, due to the difficulties inherent in credit scoring model building which involves a large number of data mining steps and requires a lot of time to process the data and build the model, efficient and accurate credit scoring methods are are urgently required. Aiming to solve this problem, we propose BACS, an blockchain and automated machine learning based classification model using credit dataset so that the credit modelling processes are performed in the pipeline in an automated manner to eventually obtain the classification results of credit scoring.
BACS scheme consists of credit data storage to blockchain, feature extraction, feature selection, modelling algorithm and hyperparameter optimization, and model evaluation. Firstly, we propose a mechanism for credit data management and storage using blockchain to ensure that the entire credit scoring system is traceable and that the information of each scoring candidate is securely, efficiently and tamper-proofly stored on the blockchain nodes.
Next, we design a pipeline using a random forest model to effectively integrate the key steps of credit data feature extraction, feature selection, credit model construction, and model evaluation. The experimental results demonstrate that our proposed automated machine learning-based credit scoring classification scheme BACS can assess the credit condition efficiently and accurately.
Sectoral Productivity Growth, COVID-19 Shocks, and Infrastructure
This paper examines sectoral productivity shocks of the COVID-19 pandemic, their aggregate impact, and the possible compensatory effects of improving productivity in infrastructure-related sectors. We employ the KLEMS annual dataset for a group of OECD and Latin America and the Caribbean countries, complemented with high-frequency data for 2020. First, we estimate a panel vector autoregression of growth rates in sector level labor productivity to specify the nature and size of sectoral shocks using the historical data.
We then run impulse-response simulations of one standard deviation shocks in the sectors that were most affected by COVID-19. We estimate that the pandemic cut economy-wide labor productivity by 4.9% in Latin America, and by 3.5% for the entire sample. Finally, by modeling the long-run relationship between productivity shocks in the sectors most affected by COVID-19, we find that large productivity improvements in infrastructure-equivalent to at least three times the historical rates of productivity gains-may be needed to fully compensate for the negative productivity losses traceable to COVID-19.
Enabling efficient traceable and revocable time-based data sharing in smart city
With the assistance of emerging techniques, such as cloud computing, fog computing and Internet of Things (IoT), smart city is developing rapidly into a novel and well-accepted service pattern these days. The trend also facilitates numerous relevant applications, e.g., smart health care, smart office, smart campus, etc., and drives the urgent demand for data sharing. However, this brings many concerns on data security as there is more private and sensitive information contained in the data of smart city applications.
It may incur disastrous consequences if the shared data are illegally accessed, which necessitates an efficient data access control scheme for data sharing in smart city applications with resource-poor user terminals. To this end, we proposes an efficient traceable and revocable time-based CP-ABE (TR-TABE) scheme which can achieve time-based and fine-grained data access control over large attribute universe for data sharing in large-scale smart city applications.
To trace and punish the malicious users that intentionally leak their keys to pursue illicit profits, we design an efficient user tracing and revocation mechanism with forward and backward security. For efficiency improvement, we integrate outsourced decryption and verify the correctness of its result. The proposed scheme is proved secure with formal security proof and is demonstrated to be practical for data sharing in smart city applications with extensive performance evaluation.
Estimating Dietary Intake from Grocery Shopping Data-A Comparative Validation of Relevant Indicators in Switzerland
In light of the globally increasing prevalence of diet-related chronic diseases, new scalable and non-invasive dietary monitoring techniques are urgently needed. Automatically collected digital receipts from loyalty cards hereby promise to serve as an objective and automatically traceable digital marker for individual food choice behavior and do not require users to manually log individual meal items.
- With the introduction of the General Data Privacy Regulation in the European Union, millions of consumers gained the right to access their shopping data in a machine-readable form, representing a historic chance to leverage shopping data for scalable monitoring of food choices.
- Multiple quantitative indicators for evaluating the nutritional quality of food shopping have been suggested, but so far, no comparison has validated the potential of these alternative indicators within a comparative setting.
- This manuscript thus represents the first study to compare the calibration capacity and to validate the discrimination potential of previously suggested food shopping quality indicators for the nutritional quality of shopped groceries, including the Food Standards Agency Nutrient Profiling System Dietary Index (FSA-NPS DI), Grocery Purchase Quality Index-2016 (GPQI), Healthy Eating Index-2015 (HEI-2015), Healthy Trolley Index (HETI) and Healthy Purchase Index (HPI), checking if any of them performs differently from the others.
- The hypothesis is that some food shopping quality indicators outperform the others in calibrating and discriminating individual actual dietary intake. To assess the indicators’ potentials, 89 eligible participants completed a validated food frequency questionnaire (FFQ) and donated their digital receipts from the loyalty card programs of the two leading Swiss grocery retailers, which represent 70% of the national grocery market.
- Compared to absolute food and nutrient intake, correlations between density-based relative food and nutrient intake and food shopping data are stronger.
- The FSA-NPS DI has the best calibration and discrimination performance in classifying participants’ consumption of nutrients and food groups, and seems to be a superior indicator to estimate nutritional quality of a user’s diet based on digital receipts from grocery shopping in Switzerland.
SureTemp ™ Dual Convection Incubator, 130 Liters with SureTemp Data Logging Software, 115V |
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SureTemp ™ Dual Convection Incubator, 40 Liters with SureTemp Data Logging Software, 115V |
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SureTemp ™ Dual Convection Incubator, 70 Liters with SureTemp Data Logging Software, 115V |
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Hach Ethernet Cable 2M |
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